A planning committee of the National Academies of Sciences, Engineering, and Medicine will convene a public workshop exploring scientific, ethical, and regulatory implications associated with the research and development of in vitro-derived human gametes. Potential topics will explore:

1. The current state of the science for in vitro derivation of male and female gametes from embryonic or induced pluripotent stem cells, including achievements with other mammalian species, roadblocks that remain to producing human gametes, and near-term prospects for overcoming remaining scientific and technical barriers.
2. The extent to which in vitro-derived human gametes could offer new options or potentially address unmet needs for both laboratory research and for reproductive medicine.
3. The ethical or social issues that would be raised by development or potential use of in vitro-derived human gametes.
4. How research and potential reproductive use of in vitro-derived human gametes would be addressed by current regulation, and whether existing regulatory approaches address the issues discussed during the workshop.

The public workshop will feature invited presentations and discussions. The planning committee will organize the workshop, select and invite speakers and discussants, and moderate the discussions. A workshop proceedings will be prepared by a designated rapporteur based on the information gathered and discussions held during the workshop, in accordance with National Academies policies and procedures