| ACC | American Chemistry Council |
| AI | Artificial Intelligence |
| APHIS | Animal and Plant Health Inspection Service (USDA) |
| API | Application Programming Interface |
| ASPR | Assistant Secretary for Preparedness and Response |
| ASTDR | Agency for Toxic Substances and Disease Registry |
| ATF | Bureau of Alcohol, Tobacco, Firearms and Explosives |
| BARDA | Biomedical Advanced Research and Development Authority |
| BWC | Biological Weapons Convention |
| CABNSAD | Chemical and Biological Weapons Non-State Adversary Database |
| CAMEO | Computer-Aided Management of Emergency Operations |
| CBC | Chemical Biological Center |
| CBCU | Chemical Biological Countermeasures Unit |
| CBDP | Chemical and Biological Defense Program (DoD) |
| CBRN | Chemical, biological, radiological, and nuclear |
| CBRNE | Chemical, biological, radiological, nuclear, and high yield explosives |
| CCDC | Collegiate Cyber Defense Competition |
| CCG | Chemical Coordination Group |
| CCMDs | Coordinating with Combatant Commands |
| CCRP | Chemical Countermeasures Research Program |
| CDC | Centers for Disease Control and Prevention (DHS) |
| CDER | Center for Drug Evaluation and Research (FDA) |
| CEPPO | Chemical Emergency Preparedness and Prevention Office (EPA) |
| CFATS | Chemical Facility Anti-Terrorism Standards |
| CFS | Cell-free synthesis |
| CHEMM | Chemical Hazards Emergency Medical Management |
| CISA | Cybersecurity and Infrastructure Security Agency (DHS) |
| CJCS | Chairman of the Joint Chiefs of Staff |
| CJCSI | Chairman of the Joint Chiefs of Staff Instruction |
| CM | Consequence management |
| CMCU | Consequence Management Coordination Unit |
| CNGB | Chief of the National Guard Bureau |
| COI | Chemicals of interest |
| CONUS | Continental USA |
| CounterACT | Medical chemical countermeasures against chemical threats |
| COVID | Coronavirus disease |
| CPB | Customs and Border Protection (DHS) |
| CRISPR | Clustered regularly interspaced palindromic repeats |
| CSAC | Chemical Security Analysis Center |
| CSB | Chemical Safety and Hazard Investigation Board |
| CT | Office of Counter Terrorism (DOS) |
| CTR | Cooperative Threat Reduction (DOS) |
| CW, CWA | Chemical weapon, chemical weapon agent |
| CWC | Chemical Weapons Convention |
| CWMD | Countering weapons of mass destruction/chemical WMD |
| CWMDT | Countering Weapons of Mass Destruction and Terrorism |
| DASD | Under Secretary of Defense for Policy, Principal Deputy Assistant Secretary of Defense |
| DEA | Drug Enforcement Administration |
| DevCom CBC | Army R&D Center for Chemical and Biologic Defense Technology |
| DHHS | Department of Health and Human Services |
| DHS | Department of Homeland Security |
| DOC | Department of Conservation |
| DoD | Department of Defense |
| DoDD | Department of Defense Directive |
| DoDI | DoD Instruction |
| DOE | Department of Energy |
| DOG | Digital Operations Guide |
| DOI | Digital object identifier |
| DOJ | Department of Justice |
| DOS | Department of State |
| DOT | Department of Transportation |
| DTRA | Defense Threat Reduction Agency (DoD) |
| DVE | Domestic violent extremist |
| ECBC | Edgewood Chemical Biological Center |
| ECC | Office of Export Control Cooperation (DOS) |
| ECPC | Emergency Communication Preparedness Center |
| ENMOD | Environmental Modification Techniques |
| EOP | Executive Office of the President |
| EPA | Environmental Protection Agency |
| EPC | Explosive precursor chemical |
| ESF | Emergency support function |
| EXBS | Export Control and Border Security Program (DOS) |
| FBI | Federal Bureau of Investigation |
| FDA | Food and Drug Administration |
| FEMA | Federal Emergency Management Administration |
| FOUO | For official use only |
| FY | Fiscal year |
| GAO | Government Accountability Office |
| GPC | Great power competition |
| GWOT | Global War on Terrorism |
| Hazmat | Hazardous materials |
| HIRA | Hazard identification and risk assessment |
| HQ/Support | Headquarters or Support (DHS) |
| HSPD | Homeland Security Presidential Directive |
| I&A | Office of Intelligence and Analysis (DHS) |
| IAFC | International Association of Fire Chiefs |
| IC | Intelligence community/Industrial chemicals |
| ICE | Immigration and Customs Enforcement (DHS) |
| ICS | Incident Command System |
| IED | Improvised explosive device |
| INTERPOL | International Criminal Police Organization |
| IS | Islamic State |
| ISIL | Islamic State of Iraq and the Levant |
| ISIS | Islamic State in Iraq and Syria |
| ISN | International Security and Nonproliferation Bureau (DOS) |
| IST | Inherently Safer Technology |
| JFCs | Joint Force Commanders |
| JP 3-40 | Joint Publication, Countering Weapons of Mass Destruction, 2019 |
| JP 3-41 | Joint Publication, Chemical, Biological, Radiological, and Nuclear Response, 2016 |
| JPEO | Joint Program Executive Office |
| JS | Joint Staff |
| JSTO | Joint Science and Technology Office |
| LE | Law enforcement |
| LLNL | Lawrence Livermore National Laboratory |
| MCF | Microbial cell factories |
| MCM | Medical countermeasure |
| ML | Machine learning |
| MNSA | Office of Multilateral Nuclear and Security Affairs |
| NASEM | National Academies of Sciences, Engineering, and Medicine |
| NATO | North Atlantic Treaty Organization |
| NCB | Nuclear, chemical, and biological |
| NCBA | Nationwide Communications Baseline Assessment |
| NCBC | National Counterproliferation Biosecurity Center |
| NCTC | National Counterterrorism Center |
| NDAA | National Defense Authorization Act |
| NDF | Nonproliferation and Disarmament Fund (DOS) |
| NDS | National Defense Strategy |
| NDU | National Defense University |
| NECP | National Emergency Communications Plan |
| NGO | Nongovernment organization |
| NIAID | National Institute of Allergy and Infectious Disease |
| NICC | National Infrastructure Coordinating Council |
| NIH | National Institutes of Health |
| NIMS | National Incident Management System |
| NIPP | National Infrastructure Protection Plan |
| NIU | National Intelligence University |
| NNSA | National Nuclear Security Administration (DOE) |
| NRF | National Response Framework |
| NRP | National Response Plan |
| NSAID | Nonsteroidal anti-inflammatory drug |
| NSC | National Security Council |
| NSM | National Security Memorandum |
| NSS | National Security Strategy |
| NTA | Nontherapy ancillary |
| O9A | Order of Nine Angles |
| OASD | Office of the Assistant Secretary of Defense |
| OBP | Office of Bombing Protection (DHS) |
| OCONUS | Outside the Contiguous United States |
| ODNI | Office of the Director of National Intelligence |
| OET | Office of Emerging Threats |
| OIP | Office of Infrastructure Protection (DHS) |
| OP | Organophosphate |
| OPCW | Organization for the Prohibition of Chemical Weapons |
| OSD(P) | Office of the Secretary of Defense (Policy) |
| OSHA | Occupational Safety and Health Administration |
| OSTP | Office of Science and Technology Policy |
| OUSD(P) | Office of the Undersecretary of Defense for Policy |
| PANTHER | Probabilistic Analysis of National Threats and Risk Program |
| PBA | Pharmaceutical-based agent |
| PBS | Project BioShield |
| PHEMCE MYB | Public Health Emergency Medical Countermeasures Multiyear Budget |
| PHMSA | Pipeline and Hazardous Materials Safety Administration (DOT) |
| POICN | Profiles of incidents involving CBRN and non-state actors |
| POW | Prisoner of war |
| PPD | Presidential Policy Directive |
| PPE | Personal protective equipment |
| PRC | People’s Republic of China |
| PRISM | Primary Response Incident Scene Management |
| PSI | Proliferation Security Initiative |
| QHSR | Quadrennial Homeland Security Review |
| QSAR | Quantum structure activity relationship |
| R&D | Research and Development |
| RBPS | Risk-based Performance Standards |
| RCA | Riot-control Agent |
| RDT&E | Research, Development, Testing, and Evaluation |
| REMV | Racially and ethnically motivated violent extremism |
| RMP | Risk Management Program |
| S&T | Science and Technology |
| SAFECOM | Safer America Through Effective Public Safety Communication |
| SAP | Strategic Action Plan |
| SC | Strategic Communication |
| SLTT | State, local, territorial, and tribal |
| SME | Subject matter expert |
| SNRA | Strategic National Risk Assessment |
| SNS | Social Networking Service |
| SOF | Special Operations Forces |
| SOT | Statement of task |
| STEM | Science, technology, engineering, and mathematics |
| TCE | Threat Credibility Evaluation |
| THI | Toxic inhalation hazard |
| THIRA | Threat and Hazard Identification and Risk Assessment |
| TIC(s) | Toxic industrial chemical(s) |
| TIM(s) | Toxic industrial material(s) |
| TMTI | Transformational Medical Technologies Initiative |
| TRL | Technology Readiness Levels |
| TSA | Transportation Security Agency (DHS) |
| TTP | Tactics, techniques, and protocols |
| UNODC | United Nations Office on Drugs and Crime |
| UNSCR 1540 | United Nations Security Council adopted resolution 1540 |
| USAMRICD | U.S. Army Medical Research Institute of Chemical Defense |
| USCIS | United States Citizenship and Immigration Services (DHS) |
| USDA | Department of Agriculture |
| USG | United States government |
| USMS | United States Marshals Service |
| USSOCOM | United States Special Operations Command |
| USSS | United States Security Service (DHS) |
| USSTRATCOM | U.S. Strategic Command |
| VEO | Violent extremist organizations |
| VX | An extremely toxic chemical compound |
| WISER | Wireless Information System for Emergency Responders |
| WMD | Weapons of mass destruction |
| WMDD | Weapons of Mass Destruction Directorate |
| WMDSG | Weapons of Mass Destruction Strategic Group |
| WMDT | Weapons of mass destruction terrorism |
| WTC | World Trade Center |
| WWI, WWII | World War 1, World War 2 |