Charting a Future for Sequencing RNA and Its Modifications: A New Era for Biology and Medicine (2024)
Chapter: Appendix B: Public Meeting Agendas
Appendix B
Public Meeting Agendas
TOWARD SEQUENCING AND MAPPING OF RNA MODIFICATIONS: A HYBRID WORKSHOP
2101 Constitution Ave NW, Washington, DC 20037
MARCH 14–15, 2023
ROOM 120
March 14: Day 1
| 9:00 | Opening Remarks |
| Steven Moss, National Academies of Sciences, Engineering, and Medicine (NASEM); Study Director | |
| Brenda Bass, University of Utah School of Medicine; Study Committee Co-Chair | |
| Taekjip Ha, Harvard Medical School and Boston Children’s Hospital; Study Committee Co-Chair | |
| 9:15 | Summary from National Institutes of Health (NIH) Workshop |
| Fred Tyson, National Institute of Environmental Health Sciences | |
| 9:45 | Framing the Workshop |
| Kristin Koutmou, University of Michigan | |
| 10:45 | Direct Sequencing Technologies |
| Eva Novoa, Centre for Genomic Regulation (virtual) | |
| Ben Garcia, Washington University at St. Louis (virtual) | |
| Shuo Huang, Nanjing University (virtual) | |
| Marcus Stoiber, Oxford Nanopore Technologies |
| 1:15 | Session on Research and Development Around Oligonucleotide Standards |
| Oligonucleotide Synthesis: Successes and Limitations | |
| Chanfeng Zhao, TriLink Biotechnologies (virtual) | |
| Jia Sheng, University of Albany (virtual) | |
| Data and Computing Resources | |
| Eugene Yeo, University of California, San Diego (virtual) | |
| Standards for Sequencing and Mapping of RNA Modifications | |
| Mark Lowenthal, National Institute of Standards and Technology | |
| 2:45 | Lessons Learned from Large-Scale Collaborative Research Endeavors |
| Robert Cook-Deegan, Arizona State University | |
| Mark Helm, Institute of Molecular Biology in Mainz, Germany (virtual) | |
| 4:00 | Major Concerns and Possible Pitfalls Related to Sequencing and Mapping of RNA Modifications |
| Todd Lowe, University of California, Santa Cruz (virtual) | |
| Schraga Schwartz, Weizmann Institute of Science (virtual) | |
| Wendy Gilbert, Yale University (virtual) | |
| Rachel Green, Johns Hopkins University | |
| 4:45 | Wrap-up Day 1 |
March 15: Day 2
| 8:30 | Opening Remarks |
| Taekjip Ha, Harvard Medical School and Boston Children’s Hospital; Study Committee Co-Chair | |
| 8:45 | Framing the Day |
| Eckhard Jankowsky, Moderna (virtual) | |
| 9:15 | Disease and Societal Impacts of RNA Chemical Modifications |
| Fange (Kathy) Liu, University of Pennsylvania | |
| Dylan Simon, EveryLife Foundation | |
| Phillip Yeske, United Mitochondrial Disease Foundation (virtual) | |
| 10:00 | Breakout Groups to Discuss Needs for RNA Mapping and Sequencing |
| 11:15 | Presentations on Technologies, Methodologies, and Information |
| Probing the Mechanism of RNA Readers and Writers for Possible RNA Chemical Modification Mapping and Sequencing Tools | |
| Danica Fujimori, University of California, San Francisco (virtual) | |
| Phanourios Tamamis, Texas A&M University |
| Artificial Intelligence for Sequence and Structure Recognition | |
| Raphael Townshend, Atomic.AI (virtual) | |
| Mary McMahon, ReviR Therapeutics, Inc. (virtual) | |
| Cryo-Electron Microscopy for Structural Determinations of Nucleotides | |
| Elizabeth Villa, University of California, San Diego (virtual) | |
| Jeffery Kieft, University of Colorado Anschutz Medical Campus (virtual) | |
| 12:45 | Closing Remarks and Adjourn Workshop |
TOWARD SEQUENCING AND MAPPING OF RNA MODIFICATIONS: IDEATION CHALLENGE
500 Fifth St NW, Washington, DC 20001
JUNE 12–13, 2023
ROOM 208
June 12: Day 1
| 9:00 | Welcome and Introductions |
| Steven Moss, NASEM; Study Director | |
| Brenda Bass, University of Utah School of Medicine; Study Committee Co-Chair | |
| Taekjip Ha, Harvard Medical School and Boston Children’s Hospital; Study Committee Co-Chair | |
| 9:30 | Group Introductions |
| Jessica De Mouy, NASEM | |
| 10:40 | Short Presentations on Emerging Technologies and Techniques |
| 12:00 | Lunch |
| 1:00 | Brainstorming – Challenges in Mapping and Sequencing RNA Chemical Modifications |
| 2:30 | Report out on Selected Challenge(s) |
| 3:30 | Visualizing your Challenge |
| 4:45 | Close-out of Day 1 |
June 13: Day 2
| 9:00 | Day 2 Overview and Instructions |
| Steven Moss | |
| Brenda Bass | |
| 9:10 | Revisiting Yesterday’s Visual Diagram |
| 10:00 | Writing an Initial Plan of Action |
| 12:00 | Lunch |
| 1:00 | Peer Review Breakout Activity |
| 2:45 | Finish the Write-Up Using Review Comments |
| 4:30 | Adjourn Challenge and Next Steps |
Ideation Challenge Participants
Scott Abernathy, University of Cincinnati
Mark Adams, The Jackson Laboratory
Scott Aoki, Indiana University School of Medicine
Matthew Blango, Leibniz Institute for Natural Product Research and Infection Biology
Glen Mark Borchert, University of South Alabama
Norman H. L. Chiu, The University of North Carolina at Greensboro
David Courtney, Queen’s University Belfast
Ricardo De Paoli-Iseppi, University of Melbourne
Eduardo Eyras, The Australian National University
Christina Fitzsimmons, National Institutes of Health
Dragony Fu, University of Rochester
Md Zohorul Islam, National Science Agency, Australian Centre for Disease Preparedness, Geelong, Australia
Kuan-Ting Lin, Cold Spring Harbor Laboratory
Simeiyun Liu, University of California, Santa Cruz
Stefan Maas, National Institutes of Health
Siddhardha Maligireddy, National Institutes of Health
Margot Martinez-Moreno, Brown University
Marie E. Migaud, University of South Alabama
Marcos Morgan, National Institutes of Health
Dalton J. Nelson, Vanderbilt University
Dimitri Pestov, Rowan University
Thomas Preiss, Australian National University
Charles Rabolli, The Ohio State University
Asif Rayhan, University of Cincinnati
Robert Ross, Thermo Fisher Scientific
Jessica Silva-Fisher, Washington University in St. Louis
Martin A. Smith, University of Montreal
Jennifer Strasburger, National Institutes of Health
David Sturgill, National Institutes of Health
Zhangli Su, University of Alabama at Birmingham
Nikos Tapinos, Brown University
Nik Tsotakos, Penn State Harrisburg
Satenik Valesyan, University of Cincinnati
Ulf Andersson Vang Ørom, University of Aarhus
Jonah Vilseck, Indiana University School of Medicine
Blerta Xhemalce, The University of Texas at Austin
Aiming Yu, University of California, Davis
Shenglong Zhang, New York Institute of Technology
