This appendix summarizes selected recommendations, clinical guidelines, and practice advisories from professional societies and other organizations relevant to cardiovascular health before, during, after, and between pregnancy (see Table B-1). This includes topics with the most relevance—it is not a complete compendium. In addition to major U.S. professional organizations, the table includes selected international guidance (e.g., National Institute for Health and Care Excellence) that is influential in clinical practice and frequently cited in U.S. guidance.
Table B-1 is organized into four sections. The first includes recommendations specific to cardiovascular conditions and pregnancy-related cardiovascular disease (CVD) complications; recommendations are grouped by condition and type of intervention (e.g., assessment, treatment threshold, medication therapy). The second section includes recommendations on life course cardiovascular risk, postpartum transition, and interpregnancy care, and the third section addresses other conditions and lifestyle factors relevant to CVD risk. The fourth section, included for context, summarizes recommendations on general maternity care.
TABLE B-1 Selected Society, Organization, and International Guidance Relevant to Cardiovascular Disease Prevention Before, During, and After Pregnancy
| Topic | Life stage | Type | Issuing body/document (year) | Key recommendations (concise summary)a |
|---|---|---|---|---|
| Specific to Cardiovascular Conditions and Pregnancy-Related Cardiovascular Disease Complications | ||||
| Hypertensive disorders of pregnancy | Prepregnancy–PP | Risk reduction, assessment, management, follow-up | NICE guideline: Hypertension in pregnancy (NG133) (updated 2023) (NICE, 2023) |
|
| Hypertensive disorders of pregnancy | Prepregnancy–PP | Diagnosis., management | ISSHP: 2021 recommendations (Magee et al., 2022) |
|
| Chronic hypertension | Prepregnancy–PP | Assessment, management, medication | ACOG Practice Bulletin No. 203: Chronic Hypertension in Pregnancy (2019) (ACOG, 2019a) |
|
| Gestational hypertension and preeclampsia | PN–PP | Diagnosis, management | ACOG Practice Bulletin No. 222: Gestational Hypertension and Preeclampsia (2020) (ACOG, 2020) |
|
| Chronic hypertension in pregnancy | PN | Treatment threshold/management update | ACOG Practice Advisory: Clinical Guidance for the Integration of Chronic Hypertension and Pregnancy Study (April 2022) (ACOG, 2022) |
|
| Mild chronic hypertension in pregnancy | PN | Management recommendation | SMFM Statement: Antihypertensive therapy for mild chronic hypertension in pregnancy (2022) (Society for Maternal-Fetal Medicine, 2022) |
|
| Preeclampsia prevention | PN | Preventive medication (society advisory) | ACOG/SMFM Practice Advisory: Low-dose aspirin to prevent preeclampsia (Dec 2021) (ACOG, 2021) |
|
| Hypertensive disorders of pregnancy postpartum transition | PP (discharge–12 weeks) | Discharge education, monitoring, follow-up | SMFM Special Statement: PP discharge checklist for women with hypertensive disorders (2020) (Gibson and Hameed, 2020) |
|
| Topic | Life stage | Type | Issuing body/document (year) | Key recommendations (concise summary)a |
|---|---|---|---|---|
| Suspected preterm preeclampsia | PN | Diagnosis (adjunct testing) | NICE diagnostics guidance: PLGF-based testing for suspected preterm preeclampsia (HTG630) (2022) (NICE, 2022) |
|
| Antihypertensive medication safety (pregnancy) | Prepregnancy–PN | Medication | AHA/ACC and partner societies: High BP pressure in adults guideline (Jones et al., 2025) |
|
| Hypertension in pregnancy (treatment thresholds and medication safety) | Prepregnancy–PP | Medication; management targets | AHA/ACC and partner societies: High BP in adults guideline (Jones et al., 2025) |
|
| Diabetes in pregnancy | Prepregnancy–PP | Counseling, screening/assessment, management | NICE guideline: Diabetes in pregnancy (NG3) (updated 2020) (NICE, 2020) |
|
| Preexisting diabetes and pregnancy | Prepregnancy–PP | Preconception counseling, monitoring/technology, treatment, PP endocrine care | Endocrine Society and European Society of Endocrinology: Preexisting Diabetes and Pregnancy (Wyckoff et al., 2025) |
|
| Topic | Life stage | Type | Issuing body/document (year) | Key recommendations (concise summary)a |
|---|---|---|---|---|
| Diabetes in pregnancy | Prepregnancy–PP | Counseling, monitoring, treatment, PP screening | ADA Standards of Care: Management of Diabetes in Pregnancy (2024–2026) (ADA Professional Practice Committee for Diabetes, 2026) |
|
| Pregnancy-associated stroke prevention | PN & early PP (≤6 weeks) and life course | Management, risk factor evaluation | AHA/American Stroke Association Guideline: Primary Prevention of Stroke (Bushnell et al., 2024) |
|
| Chronic coronary disease and pregnancy | Prepregnancy–PP | Risk stratification, team-based care, medication | AHA/ACC/American College of Clinical Pharmacy/American Society for Preventive Cardiology/National Lipid Association/Preventive Cardiovascular Nurses Association Guideline: Chronic Coronary Disease (Virani et al., 2023) |
|
| Topic | Life stage | Type | Issuing body/document (year) | Key recommendations (concise summary)a |
|---|---|---|---|---|
| Ventricular arrhythmias & sudden cardiac death prevention | PN–PP | Medication, acute management, procedures | AHA/ACC/Heart Rhythm Society Guideline: Ventricular Arrhythmias & sudden cardiac death prevention (Al-Khatib et al., 2018) |
|
| Heart failure/cardiomyopathy in pregnancy | Prepregnancy–PP | Counseling, medication management | AHA/ACC/Heart Failure Society of America Guideline: Heart Failure (Heidenreich et al., 2022) |
|
| Adult congenital heart disease and pregnancy | Prepregnancy–PN | Risk assessment, counseling, care planning | AHA/ACC Guideline: ACHD (Stout et al., 2019) |
|
| Topic | Life stage | Type | Issuing body/document (year) | Key recommendations (concise summary)a |
|---|---|---|---|---|
| Acute kidney injury/chronic kidney disease in pregnancy | PN–PP | Management, monitoring, care coordination | NICE guideline: Acute kidney injury and chronic kidney disease (NG121) (NICE, 2019) |
|
| Heart disease in pregnancy (risk assessment and care model) | Prepregnancy–PP | Risk assessment, multidisciplinary care | NICE guideline: Intrapartum care for women with existing medical conditions or obstetric complications and their babies (2019) (NICE, 2019) |
|
| Heart disease in pregnancy (screening, diagnosis, management) | Prepregnancy–PP | Screening/assessment, diagnosis, management | ACOG Practice Bulletin No. 212: Pregnancy and Heart Disease (2019) (ACOG, 2019b) |
|
| Cardio-obstetrics team-based care | Prepregnancy/PN/PP | Care model/management framework | AHA Scientific Statement: Cardiovascular Considerations in Caring for Pregnant Patients (2020) (Mehta et al., 2020) |
|
| CVD and pregnancy (comprehensive international guideline) | Prepregnancy/PN/PP | Risk stratification, management, PP follow-up | European Society of Cardiology: 2025 Guidelines for management of CVD and pregnancy (De Backer et al., 2025) |
|
| Life Course Cardiovascular Risk, Postpartum Transition, and Interpregnancy Care | ||||
| Prepregnancy cardiovascular health optimization | Prepregnancy/interpregnancy | Risk assessment and optimization framework | AHA Scientific Statement: Optimizing Prepregnancy Cardiovascular Health (2023) (Khan et al., 2023) |
|
| Adverse pregnancy outcomes and later CVD risk | PP → life course | Risk identification and prevention framework | AHA Scientific Statement: APOs and CVD Risk (2021) (Parikh et al., 2021) |
|
| Reducing CVD risk after adverse pregnancy outcomes | PP (fourth trimester and beyond) | Clinical, health system, community interventions | AHA Scientific Statement: Opportunities in the PP Period to Reduce CVD Risk After APOs (2024) (Lewey et al., 2024) |
|
| Topic | Life stage | Type | Issuing body/document (year) | Key recommendations (concise summary)a |
|---|---|---|---|---|
| Postpartum care model | PP (0–12 weeks) | Care delivery and follow-up schedule | ACOG Committee Opinion No. 736: Optimizing PP Care (2018; endorsed by SMFM) (ACOG, 2018) |
|
| Interpregnancy care | Interpregnancy/life course | Care framework | ACOG/SMFM Obstetric Care Consensus No. 8: Interpregnancy Care (2019) (ACOG and SMFM, 2019) |
|
| Other Conditions and Lifestyle Factors Relevant to Cardiovascular Disease Risk | ||||
| Obstructive sleep apnea in pregnancy | Pregnancy–PP | Screening, diagnosis, treatment | Society of Anesthesia and Sleep Medicine + Society for Obstetric Anesthesia and Perinatology (endorsed by ACOG/SMFM): OSA in pregnancy guideline (2023) (Dominguez et al., 2023) |
|
| Mental health conditions during pregnancy and postpartum | PN–PP | Screening/diagnosis; treatment/management | ACOG: Mental Health Conditions During Pregnancy and PP (2023) (ACOG, 2023a,b) |
|
| Topic | Life stage | Type | Issuing body/document (year) | Key recommendations (concise summary)a |
|---|---|---|---|---|
| Postpartum depression (medication) | PP (≤12 months) | Medication | ACOG Clinical Practice Update (endorsed by SMFM): Zuranolone and Brexanolone for PP depression (2026) (Zuranolone and brexanolone for the treatment of postpartum depression, 2026) |
|
| General Maternity Care Delivery Guidance (Included for Context and Implementation) | ||||
| Tailored prenatal care delivery | PN | Care delivery | ACOG Clinical Consensus: Tailored Prenatal Care Delivery (2025; endorsed by multiple orgs including SMFM) (ACOG, 2025) |
|
| Intrapartum care (service organization) | Intrapartum | Service organization | NICE guideline: Intrapartum care (term births) (NG235) (updated 2025) (NICE, 2025) |
|
| Routine antenatal care (booking and clinical care) | PN | Assessment; health behavior risk inquiry | NICE guideline: Antenatal care (NG201) (2021) (NICE, 2021a) |
|
| Postnatal care (organization and delivery) | PP | Care delivery | NICE guideline: PN care (NG194) (2021) (NICE, 2021b) |
|
NOTES: a Evidence/strength ratings are shown in parentheses in the Key Recommendations column when provided by the issuing organization; not all guidance documents use an explicit grading system. Ratings reflect each organization’s own framework and are not intended for direct cross-comparison. ACC/AHA/ASA and partner societies: Class of Recommendation (COR) and Level of Evidence (LOE) are shown as (COR X; LOE Y) when both are reported. COR may be displayed as 1/2a/2b/3 (or I/IIa/IIb/III). In general: 1 (I) = recommended; 2a (IIa) = reasonable; 2b (IIb) = may be considered; 3 (III): No Benefit = not recommended (no benefit); 3 (III): Harm = potentially harmful. LOE: A = high-quality evidence; B-R = moderate-quality randomized; B-NR = moderate-quality nonrandomized; C-LD = limited data; C-EO = expert opinion. (Some publicly available slide sets report COR/Class without LOE.) European Society of Cardiology: Class of Recommendation (I, IIa, IIb, III) and Level of Evidence (A, B, C) are shown as (Class X; Level Y). Endocrine Society: Grade is shown as (1 or 2; ⊕ to ⊕⊕⊕⊕), where 1 = strong recommendation and 2 = conditional recommendation; ⊕⊕⊕⊕ = high, ⊕⊕⊕ = moderate, ⊕⊕ = low, and ⊕ = very low quality of evidence. ADA: Grades are shown as (A/B/C/E): A = clear evidence from well-conducted, generalizable studies; B = supportive evidence from well-conducted cohort or case-control studies; C = supportive evidence from poorly controlled or uncontrolled studies; E = expert consensus/clinical experience. ACC = American College of Cardiology; ACE = angiotensin-converting enzyme; ACHD = adult congenital heart disease; ACOG = American College of Obstetricians and Gynecologists; ADA = American Diabetes Association; AHA = American Heart Association; APO = adverse pregnancy outcome; ARB = angiotensin receptor blocker; ARNi = angiotensin receptor-neprilysin inhibitor; BP = blood pressure; CGM = continuous glucose monitoring; CHD = congenital heart disease; CPAP = continuous positive airway pressure; CVD = cardiovascular disease; DBP = diastolic blood pressure; GDM = gestational diabetes mellitus; GLP-1 = Glucagon-like peptide-1; HDP = hypertensive disorder of pregnancy; HF = heart failure; HTN = hypertension; ICD = implantable cardioverter-defibrillator; ISSHP = International Society for the Study of Hypertension in Pregnancy; MRA = mineralocorticoid receptor antagonist; mWHO = modified World Health Organization pregnancy risk classification; NICE = National Institute for Health and Care Excellence; NSAID = nonsteroidal anti-inflammatory; OSA = obstructive sleep apnea; PA = physical activity; PLGF = placental growth factor; PN = prenatal; PP = postpartum; PTB = preterm birth; SBP = systolic blood pressure; SGLT2i = sodium-glucose cotransporter-2 inhibitor; SMBG = self-monitoring of blood glucose; SMFM = Society for Maternal-Fetal Medicine; STOP-BANG = snoring, tired, observed, pressure, body mass index, age, neck size, and gender; TDM = type 2 diabetes mellitus; USPSTF = U.S. Preventive Services Task Force.
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