Board on Health Sciences Policy

Meeting Closed

Toward Sequencing and Mapping of RNA Modifications: Information Gathering Session on Sequencing Start-ups Focused on RNA Modifications

May 25, 2023

1:00 PM - 3:00 PM (ET)

Past

About

This information gathering session will bring together experts from biotechnology start-ups to discuss the state-of-the art for sequencing technologies, direct sequencing of RNA and their modifications, and related therapeutics. During this session, invited speakers will highlight existing technologies and research and development efforts in this space and the factors that drive innovation.

Please email ttucholski@nas.edu with your interest in attending.

WATCH THE VIDEO RECORDING

Additional Information

Is it a Closed Session event?

Institution Closed

The following committee members were present at the closed sessions of the event

Nick Adams, Markus Hafner, Brenda Bass, Jeffrey Baker, Juan Alfonzo, Kate Meyer, Nicole Martinez, Sarath Janga, Susan Baserga, Taekjip Ha, Tao Pan

The following topics were discussed in the closed sessions:

During this session, the committee received information from start-up companies on novel technologies for sequencing RNA chemical modifications, including both technical and strategic details.

Organizing Project

Toward Sequencing and Mapping of RNA Modifications

Contact

Steven Moss

(202) 334-3032
smoss@nas.edu

Disclaimer

It is essential to the National Academies mission of providing evidence-based advice that participants in any of our meetings or events avoid political or partisan statements or commentary and maintain a culture of mutual respect. The statements and presentations during our meetings or events are solely those of the individual participants and do not necessarily represent the views of other participants or the National Academy of Sciences, which is a non-partisan, tax exempt organization that includes under its Charter the National Academy of Engineering and National Academy of Medicine, and that operates the National Research Council.

Closed

Creating a Framework for Emerging Science, Technology, and Innovation in Health and Medicine: Teleconference May 24

May 24, 2023

1:00 PM - 2:30 PM (ET)

Past

About

This will be a virtual discussion among the committee developing a cross-sectoral governance framework for emerging science, technology, and innovation in health and medicine. It will be closed in its entirety.

Additional Information

Is it a Closed Session event?

Institution Closed

The following committee members were present at the closed sessions of the event

Keith Wailoo
Keith Yamamoto
Hana El-Samad
Michele Goodwin
Tony Hatch
Lisa Iezzoni
Shobita Parthsarathy
Krystal Tsosie

The following topics were discussed in the closed sessions:

The committee discussed feedback on its draft report from external reviewers.

The following materials (written documents) were made available to the committee in the closed sessions:

Draft report and comments.

Date of posting of Closed Session Summary:

June 26, 2023

Organizing Project

Creating a Framework for Emerging Science, Technology, and Innovation in Health and Medicine

Contact

Michael Berrios

MBerrios@nas.edu

Disclaimer

It is essential to the National Academies mission of providing evidence-based advice that participants in any of our meetings or events avoid political or partisan statements or commentary and maintain a culture of mutual respect. The statements and presentations during our meetings or events are solely those of the individual participants and do not necessarily represent the views of other participants or the National Academy of Sciences, which is a non-partisan, tax exempt organization that includes under its Charter the National Academy of Engineering and National Academy of Medicine, and that operates the National Research Council.

Amyotrophic Lateral Sclerosis: Accelerating Treatments and Improving Quality of Life- Meeting #2

May 17 - 18, 2023

Past

Discussion

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Agenda

Download the Agenda

About

This is the second meeting of the committee and will be conducted in closed (May 17) and open session (morning of May 18). The public session will be hybrid and participants will be able to register to attend in person (2101 Constitution Ave. NW, Washington, DC 20418) or via Zoom. The purpose of the open session is for the committee to receive information and engage in discussion with ALS nonprofit leaders about the tools they need to be more effective and impactful in their work.

Please see the agenda for the meeting below.

Additional Information

Is it a Closed Session event?

Partially Closed

The following committee members were present at the closed sessions of the event

• Alan I. Leshner (chair)
• Suma Babu
• Chelsey R. Carter
• Maceo Carter
• George Demiris
• John Dunlop
• Eva L. Feldman
• Holly Fernandez Lynch
• Ileana Howard
• Jerome E. Kurent
• Won Young Lee
• Tonya Roberts
• Rita Sattler
• Joel Shamaskin
• Joshua M. Sharfstein
• Mindy Uhrlaub

The following topics were discussed in the closed sessions:

• Academies Guidance for Media Interactions
• ALS Care Models
• ALS Therapeutic Development
• Forms of ALS
• Draft Outline
• Debrief from Public Session
• Future Public Workshops

The following materials (written documents) were made available to the committee in the closed sessions:

• Briefing Book

Organizing Project

Amyotrophic Lateral Sclerosis: Accelerating Treatments and Improving Quality of Life

Contact

Rebecca English

(202) 334-2582
renglish@nas.edu

Location

National Academy of Sciences Building

2101 Constitution Ave NW

Washington DC 20418, USA

Disclaimer

It is essential to the National Academies mission of providing evidence-based advice that participants in any of our meetings or events avoid political or partisan statements or commentary and maintain a culture of mutual respect. The statements and presentations during our meetings or events are solely those of the individual participants and do not necessarily represent the views of other participants or the National Academy of Sciences, which is a non-partisan, tax exempt organization that includes under its Charter the National Academy of Engineering and National Academy of Medicine, and that operates the National Research Council.

Workshop

Improving Systems of Follow Up Care for Traumatic Brain Injury: A Workshop

May 9, 2023

9:00 AM - 11:00 AM (ET)

Past

Materials

About

VIEW WHITE PAPER on patient engagement prepared by Scott W. Hamilton & Alan Hamilton, Ph.D.

BACKGROUND

"Mild" TBIs, including concussions, are a common condition. Nearly five million people are seen in U.S. emergency departments (EDs) for suspected brain injuries each year, accounting for 1% to 2% of all ED visits annually. A little over half of these patients, 2.8 million annually, will be diagnosed with a TBI. Of those, 95% of these injuries will be considered mild.

In part due to the longstanding expectation that most TBI patients with milder injuries will make a quick and full recovery, an estimated one-third of such patients are discharged without a treatment plan, without a referral for follow-up, and without opportunities for at-home monitoring. Yet emerging research indicates that mild TBIs can nonetheless cause long-lasting disruptions to a person's physical, cognitive, and psychoemotional well-being. Persisting symptoms commonly include headaches, dizziness, cognitive impairments, and disruptions to sleep and eye tracking, among other symptoms.

The National Academies' Forum on Traumatic Brain Injury convened a workshop to explore how improvements in clinical research, treatment guidelines, symptom monitoring, outpatient care, and health system practices could better serve adults released from emergency care following a TBI. Keeping in mind the heterogenous age, geographic, and socioeconomic civilian populations that experience TBI, the workshop will discuss such issues as whether or how to check in with patients after discharge, and the varied needs, issues, and considerations that relate to follow-up, outpatient care, and at-home symptom management for adult patients in the immediate days and months after their injury.

Organizing Project

Improving Systems of Follow Up Care for Traumatic Brain Injury: A Workshop

Contact

Victoria Chege

VChege@nas.edu

Disclaimer

It is essential to the National Academies mission of providing evidence-based advice that participants in any of our meetings or events avoid political or partisan statements or commentary and maintain a culture of mutual respect. The statements and presentations during our meetings or events are solely those of the individual participants and do not necessarily represent the views of other participants or the National Academy of Sciences, which is a non-partisan, tax exempt organization that includes under its Charter the National Academy of Engineering and National Academy of Medicine, and that operates the National Research Council.

State of the Science and Future Needs for Nonhuman Primate Model Systems: Report Release

May 4, 2023

3:00 PM - 4:00 PM (ET)

Past

About

The Committee on the State of the Science and Future Needs for Nonhuman Primate Model Systems will hold a public webinar to discuss its new consensus study report examining the current landscape of nonhuman primate use in NIH-supported biomedical research and future needs and opportunities for these models, as well as opportunities for new approach methodologies to complement or reduce reliance on nonhuman primate models. Members of the committee will provide an overview of the report’s key messages and conclusions, and there will be an opportunity for audience Q&A.

Additional Information

Is it a Closed Session event?

Not Closed

Organizing Project

State of the Science and Future Needs for Nonhuman Primate Model Systems

Contact

Autumn Downey

NHPstudy@nas.edu

Disclaimer

It is essential to the National Academies mission of providing evidence-based advice that participants in any of our meetings or events avoid political or partisan statements or commentary and maintain a culture of mutual respect. The statements and presentations during our meetings or events are solely those of the individual participants and do not necessarily represent the views of other participants or the National Academy of Sciences, which is a non-partisan, tax exempt organization that includes under its Charter the National Academy of Engineering and National Academy of Medicine, and that operates the National Research Council.

Meeting Closed

Toward Sequencing and Mapping of RNA Modifications: Committee Meeting 7

May 2, 2023

12:00 PM - 2:00 PM (ET)

Past

About

This is the seventh committee meeting of a consensus study tasked with conducting a study on direct sequencing of modifications of RNA (referred to as epitranscriptome) from humans and model organisms.

This meeting will be held over Zoom.

Additional Information

Is it a Closed Session event?

Institution Closed

The following committee members were present at the closed sessions of the event

Markus Hafner, Keith Nykamp, Mary Majumder, Susan Baserga, Nicholas Adams, Jeff Baker, Brenda Bass, Julius Beau Lucks, Kate Meyer, Lydia Contreras, Nicole Martinez, Patrick A Limbach, Sarath Janga, Taekjip Ha, Tao Pan

The following topics were discussed in the closed sessions:

During this session, the committee went into the breakout groups to discuss writing strategies for initial elements of the consensus study, to be completed at the end of 2023.

Organizing Project

Toward Sequencing and Mapping of RNA Modifications

Contact

Steven Moss

(202) 334-3032
smoss@nas.edu

Disclaimer

It is essential to the National Academies mission of providing evidence-based advice that participants in any of our meetings or events avoid political or partisan statements or commentary and maintain a culture of mutual respect. The statements and presentations during our meetings or events are solely those of the individual participants and do not necessarily represent the views of other participants or the National Academy of Sciences, which is a non-partisan, tax exempt organization that includes under its Charter the National Academy of Engineering and National Academy of Medicine, and that operates the National Research Council.

Closed

Meeting of Experts on RNA Modification Databases

April 26, 2023

11:00 AM - 1:00 PM (ET)

Past

About

This information-gathering session under the Toward Sequencing and Mapping of RNA Modifications study will focus on the use and development of databases for RNA modification sequencing and mapping. This meeting will include a 1.5 hour session open to the public and a half-hour session closed to the study planning committee. Please email the Study Director Steven Moss (smoss@nas.edu) and Hoang-Nam Vu (hvu@nas.edu) for additional information on attending the public portion of this meeting.

Additional Information

Is it a Closed Session event?

Institution Closed

The following committee members were present at the closed sessions of the event

Patrick A Limbach, Jeffrey Baker, Juan Alfonzo, Kate Meyer, Keith Nykamp, Mary Majumder, Markus Hafner, Nicholas Adams, Sarath Janga, Susan Baserga, Taekjip Ha, Tao Pan

The following topics were discussed in the closed sessions:

During this closed session, the committee heard from experts in databases used for RNA modification sequencing and mapping.

Organizing Project

Toward Sequencing and Mapping of RNA Modifications

Contact

Steven Moss

(202) 334-3032
smoss@nas.edu

Disclaimer

It is essential to the National Academies mission of providing evidence-based advice that participants in any of our meetings or events avoid political or partisan statements or commentary and maintain a culture of mutual respect. The statements and presentations during our meetings or events are solely those of the individual participants and do not necessarily represent the views of other participants or the National Academy of Sciences, which is a non-partisan, tax exempt organization that includes under its Charter the National Academy of Engineering and National Academy of Medicine, and that operates the National Research Council.

Roundtable on Mentorship, Well-Being, and Professional Development Meeting #3

April 19, 2023

1:00 PM - 3:00 PM (ET)

Past

About

This is the third Roundtable meeting. The Roundtable will explore the on-going improvements and innovations in effective mentorship and professional development practices and programs and how to create and maintain an inclusive and equitable higher education and STEMM research ecosystem.

Organizing Project

Roundtable on Mentorship, Well-Being, and Professional Development

Contact

Maria Lund Dahlberg

Disclaimer

It is essential to the National Academies mission of providing evidence-based advice that participants in any of our meetings or events avoid political or partisan statements or commentary and maintain a culture of mutual respect. The statements and presentations during our meetings or events are solely those of the individual participants and do not necessarily represent the views of other participants or the National Academy of Sciences, which is a non-partisan, tax exempt organization that includes under its Charter the National Academy of Engineering and National Academy of Medicine, and that operates the National Research Council.

Workshop

In Vitro Derived Human Gametes as a Reproductive Technology: Scientific, Ethical, and Regulatory Implications: A Workshop

April 19 - 21, 2023

Past

Materials

About

VIEW AGENDA

April 19, 2023 | 9:15 am-5:00 pm ET
April 20, 2023 | 9:30 am-5:00 pm ET
April 21, 2023 | 9:30 am-2:30 pm ET

BACKGROUND

Progress in the in vitro derivation of human gametes (eggs and sperm) continues to advance. Although a number of technical gaps remain to be overcome, partial reconstitution of human gamete production has been reported for both male and female pathways. Human primordial germ cell like cells (PGCLCs) can be created from induced pluripotent stem cells, “oogonia-like” cells have been derived in culture, and limited parts of the human sperm pathway have been achieved.

Laboratory studies reconstituting gamete development can advance understanding of how this process proceeds in early human development and what genes are responsible at different stages of the pathway. Were in vitro human gametes ever approved for clinical use, however, they could provide a novel option for prospective parents and significantly alter the practice of reproductive medicine. Somatic cells taken from parents theoretically could be converted to iPSCs, further differentiated into functional gametes, and these gametes used to create a human embryo through in vitro fertilization. This ability could enable couples who are not otherwise able to do so (for example because of conditions such as infertility or same-sex couples) to produce embryos that are genetically related to both parents.

The ability to generate large numbers of embryos also could enable many parents who carry known disease-causing mutations to undertake highly efficient preimplantation genetic screening and establish a pregnancy only with an embryo that does not carry that mutation. The ability to genome edit in gamete precursor cells provides yet another possibility that could enable prospective parents to produce embryos without a disease-causing genome, representing a potential alternative pathway for undertaking heritable genome editing.

Any use of in vitro-derived human gametes would raise important scientific, ethical, social, and regulatory issues. These are not questions that can be answered by scientific, bioethics, and regulatory communities alone– they will require broader societal engagement. In anticipation of continued research developments, however, now is the time to review the state of the science, understand what is driving progress in this area, what is likely to be achievable and what is likely not to be realistic, and recognize the urgent issues that in vitro-derived gametes could raise. A careful assessment now would provide foundational analysis to inform the development of future consultative social, legislative, or regulatory discussions.

Organizing Project

In Vitro Derived Human Gametes as a Reproductive Technology: Scientific, Ethical, and Regulatory Implications

Contact

Ashley Bologna

ABologna@nas.edu

Location

Keck Center

500 5th St NW

Washington DC 20001, USA

Disclaimer

It is essential to the National Academies mission of providing evidence-based advice that participants in any of our meetings or events avoid political or partisan statements or commentary and maintain a culture of mutual respect. The statements and presentations during our meetings or events are solely those of the individual participants and do not necessarily represent the views of other participants or the National Academy of Sciences, which is a non-partisan, tax exempt organization that includes under its Charter the National Academy of Engineering and National Academy of Medicine, and that operates the National Research Council.

Closed

Integrating the Human Sciences to Scale Societal Responses to Environmental Change: Planning Meeting #9

April 18, 2023

3:00 PM - 3:20 PM (ET)

Past

About

The workshop planning committee will be reviewing the agenda and finalizing speakers.

Organizing Project

Integrating the Human Sciences to Scale Societal Responses to Environmental Change: A Workshop

Contact

Sitara Rahiab

(202) 334-2269
srahiab@nas.edu

Disclaimer

It is essential to the National Academies mission of providing evidence-based advice that participants in any of our meetings or events avoid political or partisan statements or commentary and maintain a culture of mutual respect. The statements and presentations during our meetings or events are solely those of the individual participants and do not necessarily represent the views of other participants or the National Academy of Sciences, which is a non-partisan, tax exempt organization that includes under its Charter the National Academy of Engineering and National Academy of Medicine, and that operates the National Research Council.

Closed

Creating a Framework for Emerging Science, Technology, and Innovation in Health and Medicine: Teleconference April 17

April 17, 2023

12:00 PM - 1:30 PM (ET)

Past

About

This will be a virtual discussion among the committee developing a cross-sectoral governance framework for emerging science, technology, and innovation in health and medicine. It will be closed in its entirety.

Additional Information

Is it a Closed Session event?

Institution Closed

The following committee members were present at the closed sessions of the event

Keith Wailoo
Keith Yamamoto
Olveen Carrasquillo
Alta Charo
Hana El-Samad
Michele Goodwin
Jianying Hu
Lisa Iezzoni
Alex London
Kaushik S. Rajan
Timothy Persons
Krystal Tsosie

The following topics were discussed in the closed sessions:

The committee discussed feedback on its draft report from external reviewers.

The following materials (written documents) were made available to the committee in the closed sessions:

Draft report and comments.

Date of posting of Closed Session Summary:

June 26, 2023

Organizing Project

Creating a Framework for Emerging Science, Technology, and Innovation in Health and Medicine

Contact

Michael Berrios

MBerrios@nas.edu

Disclaimer

It is essential to the National Academies mission of providing evidence-based advice that participants in any of our meetings or events avoid political or partisan statements or commentary and maintain a culture of mutual respect. The statements and presentations during our meetings or events are solely those of the individual participants and do not necessarily represent the views of other participants or the National Academy of Sciences, which is a non-partisan, tax exempt organization that includes under its Charter the National Academy of Engineering and National Academy of Medicine, and that operates the National Research Council.

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Board on Health Sciences Policy

Toward Sequencing and Mapping of RNA Modifications: Information Gathering Session on Sequencing Start-ups Focused on RNA Modifications

Creating a Framework for Emerging Science, Technology, and Innovation in Health and Medicine: Teleconference May 24

Amyotrophic Lateral Sclerosis: Accelerating Treatments and Improving Quality of Life- Meeting #2

Examining the Working Definition for Long COVID - Committee Meeting 3

Improving Systems of Follow Up Care for Traumatic Brain Injury: A Workshop

State of the Science and Future Needs for Nonhuman Primate Model Systems: Report Release

Integrating the Human Sciences to Scale Societal Responses to Environmental Change: A Workshop

Toward Sequencing and Mapping of RNA Modifications: Committee Meeting 7

Meeting of Experts on RNA Modification Databases

Addressing Health Disparities in Central Nervous System Disorders: Virtual Workshop #3

Roundtable on Mentorship, Well-Being, and Professional Development Meeting #3

In Vitro Derived Human Gametes as a Reproductive Technology: Scientific, Ethical, and Regulatory Implications: A Workshop

Integrating the Human Sciences to Scale Societal Responses to Environmental Change: Planning Meeting #9

Addressing Health Disparities in Central Nervous System Disorders: Virtual Workshop #2

Creating a Framework for Emerging Science, Technology, and Innovation in Health and Medicine: Teleconference April 17